{"product_id":"topical-dutasteride-60-ml","title":"Dutasteride (Topical)","description":"\u003cdiv style=\"max-width:820px;margin:0 auto;padding:20px 0;color:#122026;line-height:1.6\"\u003e\n\u003ch2 style=\"color:#154ba3\"\u003eTopical Dutasteride — 60 mL\u003c\/h2\u003e\n\u003cp\u003eDutasteride is a synthetic 4-azasteroid supplied here as a liquid research solution in an ethanol and USP propylene glycol vehicle.\u003c\/p\u003e\n\u003cdiv style=\"background:#f7faff;border-left:4px solid #154ba3;border-radius:12px;padding:16px;margin:18px 0\"\u003e\n\u003ch3 style=\"color:#154ba3\"\u003eKey Research Areas\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eType 1 and type 2 5-alpha-reductase inhibition\u003c\/li\u003e\n\u003cli\u003eTestosterone conversion to dihydrotestosterone (DHT)\u003c\/li\u003e\n\u003cli\u003eAndrogen signaling in follicular models\u003c\/li\u003e\n\u003cli\u003eSolution and vehicle comparisons\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003ch3 style=\"color:#154ba3\"\u003eMechanism of Interest\u003c\/h3\u003e\n\u003cp\u003eDutasteride inhibits type 1 and type 2 5-alpha-reductase, the enzymes that convert testosterone to DHT. Its mechanism acts at the level of DHT synthesis. \u003ca href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=960797b3-09b1-4d6a-8ece-8b5d918e93e4\"\u003eDutasteride pharmacology reference\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3 style=\"color:#154ba3\"\u003eProduct Details\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid solution, 60 mL bottle\u003cbr\u003e\u003cstrong\u003eCompound:\u003c\/strong\u003e Dutasteride\u003cbr\u003e\u003cstrong\u003eCompound class:\u003c\/strong\u003e Synthetic 4-azasteroid, dual 5-alpha-reductase inhibitor\u003c\/p\u003e\n\u003ch4 style=\"color:#e8edf5\"\u003e0.1% w\/v\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eDutasteride:\u003c\/strong\u003e 1 mg\/mL (60 mg per bottle)\u003c\/p\u003e\n\u003ch4 style=\"color:#e8edf5\"\u003e0.3% w\/v\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eDutasteride:\u003c\/strong\u003e 3 mg\/mL (180 mg per bottle)\u003c\/p\u003e\n\u003ch4 style=\"color:#e8edf5\"\u003eVehicle and volume for both strengths\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003eEthanol:\u003c\/strong\u003e 40 mL (66.67% v\/v)\u003cbr\u003e\u003cstrong\u003eUSP propylene glycol:\u003c\/strong\u003e 20 mL (33.33% v\/v)\u003cbr\u003e\u003cstrong\u003eTarget final volume:\u003c\/strong\u003e 60 mL\u003c\/p\u003e\n\u003ch3 style=\"color:#154ba3\"\u003ePublished Research and Formulation Limits\u003c\/h3\u003e\n\u003cp\u003eThe 2025 randomized Phase II trial evaluated direct scalp application of dutasteride solutions at 0.01%, 0.02%, and 0.05% w\/v (0.1, 0.2, and 0.5 mg\/mL). The 0.1% and 0.3% formulations listed here are two and six times the highest concentration tested, respectively. The trial does not establish safety, efficacy, or absorption for either listed formulation. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12405733\/\"\u003ePanuganti et al., 2025 Phase II trial\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eA separate randomized placebo-controlled study evaluated topical dutasteride alongside microneedling. Its findings apply to the combined intervention and do not establish the effects of conventional topical application alone. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35648446\/\"\u003eSánchez-Meza et al., 2022 microneedling study\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThe literature review discusses delivery approaches and the role of the vehicle in skin penetration. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11875473\/\"\u003eTopical dutasteride literature review\u003c\/a\u003e\u003c\/p\u003e\n\u003cdiv style=\"background:#154ba3;color:#fff;border-radius:12px;padding:16px;margin-top:22px\"\u003e\n\u003cstrong\u003eResearch Use Only\u003c\/strong\u003e\u003cp\u003eFor laboratory research only. Not for human consumption, medical, diagnostic, or therapeutic use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Method Peptides","offers":[{"title":"0.3% w\/v","offer_id":50760267792522,"sku":null,"price":80.0,"currency_code":"USD","in_stock":true},{"title":"0.1% w\/v","offer_id":50760267825290,"sku":null,"price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0611\/5531\/1754\/files\/1mg-DutasterideResearchDropperBottle.png?v=1794280607","url":"https:\/\/methodpeptides.com\/products\/topical-dutasteride-60-ml","provider":"Method Peptides","version":"1.0","type":"link"}